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The State Department said it was “closely monitoring the situation and is deploying a disaster response adviser to the region to support response efforts. The Department will also provide $500,000 in assistance through its global award with Catholic Relief Services, supporting emergency shelter, relief items, and water, sanitation, and hygiene assistance to flood-affected communities.”

Secretary of State Marco Rubio also expressed American solidarity with Nepal and said the United States stood ready to assist the country’s government with humanitarian needs as the full scale of the catastrophe emerged.

The U.S. Embassy in Nepal said it was “working to account for U.S. citizens who may have been affected” and urged Americans in the disaster zone who were able to communicate to contact their families, hotels, guides, trekking companies or tour operators as quickly as possible.

Communications remain severely disrupted in portions of the region, creating the possibility that some people currently classified as missing or out of contact could ultimately be found alive once cellphone networks and transportation links are restored.

Among those caught in the disaster were travelers associated with the India-based Isha Foundation, which told ABC News that 22 Americans were among a 77-person tour group at an immigration center near the Nepal-Tibet border when the flooding struck.

Three additional missing Americans were reportedly traveling with the Nepalese company Fishtail Tours and Travel, which confirmed that the U.S. nationals were among tourists still unaccounted for.

The disaster reportedly began roughly 12 miles northeast of the Rasuwagadhi border crossing, where an enormous glacial collapse sent ice, rock, and debris plunging into the valley before a devastating surge traveled downstream toward populated areas.

Entire stretches of critical infrastructure have been devastated, complicating an already dangerous rescue mission as emergency crews navigate unstable terrain, thick mud, high water, and areas accessible primarily by helicopter.